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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SCN5A
All Species:
13.03
Human Site:
T486
Identified Species:
31.85
UniProt:
Q14524
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14524
NP_000326.2
2016
226940
T486
R
K
R
M
S
S
G
T
E
E
C
G
E
D
R
Chimpanzee
Pan troglodytes
XP_001171891
2016
226990
T486
R
K
R
M
S
S
G
T
E
E
C
G
E
D
R
Rhesus Macaque
Macaca mulatta
XP_001099916
2017
229324
G536
E
D
S
I
R
R
K
G
F
R
F
S
L
E
G
Dog
Lupus familis
XP_849362
2012
228642
G536
E
D
S
I
R
R
K
G
F
R
F
S
L
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9JJV9
2019
227604
T486
R
K
R
L
S
S
G
T
E
D
G
G
D
D
R
Rat
Rattus norvegicus
P15389
2019
227349
T487
R
K
R
L
S
S
G
T
E
D
G
G
D
D
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232818
2040
231951
E485
K
K
K
S
L
G
A
E
E
Y
G
E
D
Q
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q20JQ7
1784
201644
F371
Y
D
N
F
G
W
A
F
L
A
L
F
R
L
M
Tiger Blowfish
Takifugu rubipres
Q2XVR7
1892
213080
A467
A
Q
V
L
G
S
R
A
S
L
T
S
K
K
S
Fruit Fly
Dros. melanogaster
P35500
2131
239344
H544
Q
P
A
P
T
T
A
H
Q
A
T
K
V
R
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
64.5
64.6
N.A.
94.4
94
N.A.
N.A.
76.4
N.A.
57.5
58.1
44
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
77
77.1
N.A.
96.5
96.2
N.A.
N.A.
85.1
N.A.
69.8
70.7
60.3
N.A.
N.A.
N.A.
P-Site Identity:
100
100
0
0
N.A.
73.3
73.3
N.A.
N.A.
20
N.A.
0
6.6
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
13.3
13.3
N.A.
93.3
93.3
N.A.
N.A.
40
N.A.
0
26.6
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
0
0
30
10
0
20
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% C
% Asp:
0
30
0
0
0
0
0
0
0
20
0
0
30
40
0
% D
% Glu:
20
0
0
0
0
0
0
10
50
20
0
10
20
20
0
% E
% Phe:
0
0
0
10
0
0
0
10
20
0
20
10
0
0
0
% F
% Gly:
0
0
0
0
20
10
40
20
0
0
30
40
0
0
20
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
50
10
0
0
0
20
0
0
0
0
10
10
10
10
% K
% Leu:
0
0
0
30
10
0
0
0
10
10
10
0
20
10
0
% L
% Met:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
0
10
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
10
10
0
0
0
0
0
0
10
0
0
0
0
10
0
% Q
% Arg:
40
0
40
0
20
20
10
0
0
20
0
0
10
10
50
% R
% Ser:
0
0
20
10
40
50
0
0
10
0
0
30
0
0
10
% S
% Thr:
0
0
0
0
10
10
0
40
0
0
20
0
0
0
0
% T
% Val:
0
0
10
0
0
0
0
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _